Apoptosis is mediated by proteolytic enzymes called caspases, which trigger cell death by cleaving specific proteins in the cytoplasm and nucleus. Caspases exist in all cells as inactive precursors, or procaspases, which are usually activated by cleavage by other caspases, producing a proteolytic caspase cascade.
Subsequently, one may also ask, what organelle is responsible for Apoptosis?
Indeed, the mitochondria are central regulators of apoptosis. Outer mitochondrial membrane proteins Bcl-2, the BH3-only proteins and Bax are involved: Bax can form a pore in the membrane to allow cytochrome c, normally located in the intermembrane space, out into the cytosol.
What is dysregulated apoptosis?
Dysregulation of apoptosis in cancer. The morphologic ritual cells go through when experiencing PCD has been termed apoptosis and is executed by a family of intracellular proteases, called caspases.
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