Carbonic anhydrase inhibitors (eg, acetazolamide) and loop diuretics (eg, furosemide) are thought to exert their effect on ICP by reducing cerebrospinal fluid (CSF) production at the choroid plexus. Cardiac glycosides have a similar effect.
What is the normal range for intracranial pressure?
A standing adult generally has an ICP of -10 mm Hg but never less than -15 mm Hg. In supine children, ICP is normally lower, in the range of 15 mm Hg, with infants having ICP from 5-10 mm Hg and newborns have subatmospheric pressures regardless of position.
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